Fitzsimmons D, Johnson C D
University Surgical Unit, Southampton General Hospital, UK.
Langenbecks Arch Surg. 1998 Apr;383(2):145-51. doi: 10.1007/s004230050106.
In the past decade there has been increasing focus on assessment of the quality of life (QoL) of patients with cancer. QoL is now a mandatory endpoint in many cancer clinical trials, particularly in interventions with palliative intent alone. Although QoL is difficult to define, a variety of specially designed and validated questionnaires has been developed to measure QoL in the clinical setting. In pancreatic cancer, assessment (QoL) is of paramount importance; however, little research has been conducted and until recently no disease-specific QoL questionnaire existed. In this review we consider the quality of life of patients with pancreatic cancer, with particular reference to the symptoms and psychosocial consequences of the disease. The literature is critically examined on the approaches to evaluation of QoL in previous pancreatic cancer clinical trials. We then describe the impact on QoL following both "curative" and palliative surgical interventions and medical treatment, including endoscopic palliation and chemotherapy for pancreatic cancer. In the European Organisation for Research and Treatment of Cancer (EORTC) the questionnaire specific for pancreatic cancer, the QLQ-PAN26, is discussed as a standardised and valid assessment of QoL in international clinical trials. Finally, recommendations are made for future QoL research in pancreatic cancer.
在过去十年中，对癌症患者生活质量（QoL）的评估越来越受到关注。如今，生活质量已成为许多癌症临床试验中的一个强制性终点，尤其是在仅具有姑息治疗意图的干预措施中。尽管生活质量难以定义，但已经开发了各种专门设计并经过验证的问卷，用于在临床环境中测量生活质量。在胰腺癌中，评估（生活质量）至关重要；然而，相关研究甚少，直到最近还没有针对该疾病的特定生活质量问卷。在这篇综述中，我们探讨了胰腺癌患者的生活质量，特别提及了该疾病的症状和心理社会影响。对以往胰腺癌临床试验中生活质量评估方法的文献进行了批判性审视。然后，我们描述了“根治性”和姑息性手术干预以及药物治疗（包括胰腺癌的内镜姑息治疗和化疗）对生活质量的影响。在欧洲癌症研究与治疗组织（EORTC）中，专门针对胰腺癌的问卷QLQ - PAN26，被作为国际临床试验中生活质量的标准化有效评估方法进行了讨论。最后，对未来胰腺癌生活质量研究提出了建议。
