Loo T W, Clarke D M
Department of Medicine and Department of Biochemistry, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.
Biochem Biophys Res Commun. 1998 Jun 18;247(2):478-80. doi: 10.1006/bbrc.1998.8823.
Alkylphenol ethoxylates are surfactants that are commonly used in industry and in home care products. They are broken down by anaerobes to yield toxic environmental pollutants such as nonylphenol. In this study, we tested whether nonylphenol ethoxylates and their most common biodegradation product, nonylphenol, were substrates of human P-glycoprotein. In vivo and in vitro assays showed that the enzyme interacts with a wide variety of nonylphenol ethoxylate compounds, but not with nonylphenol. These results suggest that P-glycoprotein can protect organisms from the toxic and estrogenic effects of nonylphenol ethoxylates, but not from the major biodegradation product, nonylphenol.
烷基酚聚氧乙烯醚是常用于工业和家庭护理产品的表面活性剂。它们被厌氧菌分解后会产生有毒的环境污染物，如壬基酚。在本研究中，我们测试了壬基酚聚氧乙烯醚及其最常见的生物降解产物壬基酚是否是人类P-糖蛋白的底物。体内和体外试验表明，该酶与多种壬基酚聚氧乙烯醚化合物相互作用，但不与壬基酚相互作用。这些结果表明，P-糖蛋白可以保护生物体免受壬基酚聚氧乙烯醚的毒性和雌激素作用，但不能免受主要生物降解产物壬基酚的影响。
