Persson B C, Atkins J F
Howard Hughes Medical Institute, University of Utah, Salt Lake City 84112-5330, USA.
J Bacteriol. 1998 Jul;180(13):3462-6. doi: 10.1128/JB.180.13.3462-3466.1998.
In Escherichia coli an autoregulatory mechanism of programmed ribosomal frameshifting governs the level of polypeptide chain release factor 2. From an analysis of 20 sequences of genes encoding release factor 2, we infer that this frameshift mechanism was present in a common ancestor of a large group of bacteria and has subsequently been lost in three independent lineages.
在大肠杆菌中,程序性核糖体移码的一种自我调节机制控制着多肽链释放因子2的水平。通过对20个编码释放因子2的基因序列进行分析,我们推断这种移码机制存在于一大群细菌的共同祖先中,并且随后在三个独立的谱系中丢失了。