Forward G C, James A H, Barnett P, Jackson R J
SmithKline Beecham Consumer Health Care Research Department, Weybridge, Surrey, United Kingdom.
Periodontol 2000. 1997 Oct;15:32-9. doi: 10.1111/j.1600-0757.1997.tb00102.x.
Two dominant factors dictate which ingredients are used in formulating toothpaste and mouthwashes. The major one is the type of active ingredient chosen, especially cationic active ingredients such as chlorhexidine; the other factor is the needs of the consumer. Apart from gum health benefits, the consumer expects to obtain from gum health toothpaste and mouthwashes other benefits of clean teeth (abrasive and detergent), fresh breath (antimicrobial agents and flavor) and protection from caries and possibly tartar. Exhaustive testing involving experimental design and validated laboratory and clinical tests is essential to ensure that all these benefits are delivered. Unless products are developed systematically, then products with relatively poor activity can find their way on to the market.
有两个主要因素决定了牙膏和漱口水配方中使用哪些成分。主要因素之一是所选择的活性成分类型，尤其是阳离子活性成分，如洗必泰；另一个因素是消费者的需求。除了对牙龈健康有益外，消费者还期望从牙龈健康牙膏和漱收水中获得清洁牙齿的其他益处（研磨和清洁作用）、清新口气（抗菌剂和香料）以及预防龋齿和可能的牙垢。进行涉及实验设计以及经过验证的实验室和临床试验的详尽测试，对于确保实现所有这些益处至关重要。除非产品是系统开发的，否则活性相对较差的产品可能会进入市场。
