Shahinian H K, Jaekle R, Suh R H, Jarrahy R, Aguilar V C, Soojian M
Division of Skull Base Surgery, Skull Base Institute, Cedars-Sinai Medical Center, USA.
Am J Perinatol. 1998 May;15(5):281-6. doi: 10.1055/s-2007-993943.
Lambdoid synostosis results in skull deformities of varying degrees characterized by occipital flattening over the involved suture and other compensatory changes in skull shape. Such changes include contralateral occipital bossing, contralateral frontal flattening, ipsilateral frontal bossing, and ipsilateral anteroinferior displacement of the pinna (ear shearing). These deformities tend to worsen during the first year of life. The etiology has been attributed to genetic factors and primary disorders of bone growth, in addition to secondary effects of other diseases and modulators of the in utero environment. To determine causal factors in the development of lambdoid synostosis, the authors reviewed medical records of the mothers of 13 children with lambdoid synostosis who were treated at the University Medical Center of the State University of New York at Stony Brook. Pre- and perinatal events, prior obstetrical, gynecological, medical, social, and family histories were considered. Births of normal infants immediately prior to and just after the affected babies were born were selected as controls. There is a significant association between increased duration of the first stage of labor and the development of lambdoid synostosis. Furthermore, our results indicate that this condition has a predilection toward male infants, and may be associated with preterm labor.
人字缝早闭会导致不同程度的颅骨畸形，其特征是受累缝上方的枕骨扁平以及颅骨形状的其他代偿性变化。这些变化包括对侧枕骨膨隆、对侧额骨扁平、同侧额骨膨隆以及耳廓同侧前下移位（耳部剪切）。这些畸形在出生后第一年往往会加重。病因除了其他疾病和子宫内环境调节因子的继发作用外，还归因于遗传因素和骨生长的原发性疾病。为了确定人字缝早闭发展中的因果因素，作者回顾了在纽约州立大学石溪分校大学医学中心接受治疗的13名人字缝早闭患儿母亲的病历。考虑了产前和围产期事件、既往产科、妇科、医疗、社会和家族病史。选择在受影响婴儿出生前后立即出生的正常婴儿作为对照。第一产程时间延长与人字缝早闭的发生之间存在显著关联。此外，我们的结果表明，这种情况在男婴中更常见，并且可能与早产有关。
