Jinza S, Takano Y, Iki M, Noguchi S, Masuda M
Department of Urology, Yokohama City University School of Medicine, Japan.
Urol Int. 1998;60(3):147-51. doi: 10.1159/000030239.
Fifty-three patients with invasive transitional cell carcinoma of the renal pelvis and ureter were studied for p53 protein overexpression by immunohistochemistry. Overexpression of p53 protein was observed in 19 patients (35.8%). There was a significant correlation between overexpression of p53 protein and histologic grade (p < 0.01). However, there was no correlation found between p53 immunoreactivity and pathologic stage. By univariate survival analysis, a significant difference in cumulative survival was observed between stage pT2 and stage pT3 or pT4 tumors (p < 0.05). The difference in survival between patients with p53-positive and negative tumors did not reach statistical significance (0.05 < p < 0.01). Multivariate analysis revealed that pathologic stage had an independent prognostic value (p < 0.05). The independent prognostic value of p53 protein overexpression did not quite reach statistical significance (p = 0.07). p53 protein nuclear overexpression appears to be a relatively weak prognostic indicator for patients with invasive transitional cell carcinoma of the renal pelvis and ureter.
采用免疫组织化学方法对53例肾盂及输尿管浸润性移行细胞癌患者进行p53蛋白过表达研究。19例患者（35.8%）观察到p53蛋白过表达。p53蛋白过表达与组织学分级之间存在显著相关性（p < 0.01）。然而，未发现p53免疫反应性与病理分期之间存在相关性。单因素生存分析显示，pT2期与pT3期或pT4期肿瘤的累积生存率存在显著差异（p < 0.05）。p53阳性和阴性肿瘤患者的生存率差异未达到统计学意义（0.05 < p < 0.01）。多因素分析显示，病理分期具有独立的预后价值（p < 0.05）。p53蛋白过表达的独立预后价值未完全达到统计学意义（p = 0.07）。p53蛋白核过表达似乎是肾盂及输尿管浸润性移行细胞癌患者相对较弱的预后指标。
