Electron microscopic examination of Aedes albopictus clone C6/36 cells infected with dengue virus 2 at elevated incubation temperature.

Morphological changes such as loss of cytoplasm, membrane destruction and vacuolar swelling in Aedes albopictus clone C6/36 cells infected with dengue virus 2 (DV-2) New Guinea B strain and incubated at 28 degrees C and 37 degrees C, were observed under electron microscope. Both infected and uninfected cells showed significant damage at 37 degrees C in contrast to normal appearance at 28 degrees C. A higher number of virus particles were observed in the cytoplasm at 37 degrees C than at 28 degrees C.