Gutteridge J M, Quinlan G J, Yamamoto Y
Oxygen Chemistry Laboratory, Royal Brompton Hospital, London.
Free Radic Res. 1998 Feb;28(2):109-14. doi: 10.3109/10715769809065796.
Several unrelated diseases show plasma and tissue fatty acid patterns characteristic of those seen in Essential Fatty Acid Deficiency Disease (EFADD). A common feature occurring in all these diseases is oxidative stress. We hypothesize that reactive oxygen species or products of oxidative damage, particularly those derived from lipids, act as signal molecules to alter desaturase enzymes and induce the fatty acid patterns characteristic of EFADD.
几种不相关的疾病呈现出与必需脂肪酸缺乏症（EFADD）中所见相似的血浆和组织脂肪酸模式。所有这些疾病共有的一个特征是氧化应激。我们推测活性氧或氧化损伤产物，尤其是那些源自脂质的产物，作为信号分子改变去饱和酶并诱导出EFADD特有的脂肪酸模式。
