Santamarina-Fojo S, Haudenschild C, Amar M
Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Curr Opin Lipidol. 1998 Jun;9(3):211-9. doi: 10.1097/00041433-199806000-00005.
In addition to its traditional role in the hydrolysis of lipoprotein triglycerides and phospholipids, recent studies have implicated hepatic lipase in other aspects of cellular lipid and/or lipoprotein metabolism and atherosclerosis. Hepatic lipase may serve as a ligand that mediates the interaction of lipoproteins to cell surface receptors and/or proteoglycans as well as modulating aortic lesion development in different animal models. Over the past several years significant advances have been made in our understanding of new, alternative mechanisms by which hepatic lipase may modulate lipoprotein metabolism and the development of atherosclerosis in vivo.
除了在脂蛋白甘油三酯和磷脂水解中的传统作用外，最近的研究表明肝脂酶在细胞脂质和/或脂蛋白代谢以及动脉粥样硬化的其他方面也有涉及。肝脂酶可能作为一种配体，介导脂蛋白与细胞表面受体和/或蛋白聚糖的相互作用，以及调节不同动物模型中主动脉病变的发展。在过去几年里，我们对肝脂酶可能在体内调节脂蛋白代谢和动脉粥样硬化发展的新的、替代机制的理解取得了重大进展。
