Tikkanen M J, Nikkilä E A
Am Heart J. 1987 Feb;113(2 Pt 2):562-7. doi: 10.1016/0002-8703(87)90633-8.
The influence of sex steroids on the serum lipoprotein pattern was recognized more than 30 years ago, and it still remains among the areas of major interest. This is because of the compatible sex difference in plasma lipoprotein pattern and in coronary heart disease risk. Recent discoveries of the role of hepatic lipase in lipoprotein metabolism have elucidated mechanisms behind sex steroid-induced changes in lipoproteins. These steroids regulate the activity of hepatic lipase, an enzyme bound to the endothelial cells of liver sinusoids. Hepatic lipase has a central role in the removal of phospholipids and triglycerides from subfractions of high-density lipoprotein (HDL2) particles, but it may also function in the lipolysis of triglyceride-rich particles. Some older and more recent developments in this area will be reviewed.
30多年前人们就认识到性类固醇对血清脂蛋白模式的影响，它至今仍是主要研究领域之一。这是因为血浆脂蛋白模式和冠心病风险存在性别差异。最近关于肝脂酶在脂蛋白代谢中作用的发现阐明了性类固醇诱导脂蛋白变化背后的机制。这些类固醇调节肝脂酶的活性，肝脂酶是一种与肝血窦内皮细胞结合的酶。肝脂酶在从高密度脂蛋白（HDL2）颗粒亚组分中去除磷脂和甘油三酯方面起着核心作用，但它也可能在富含甘油三酯颗粒的脂解中发挥作用。本文将综述该领域一些早期和近期的进展。
