Vidal M V, Gutfilen B, da Fonseca L M, Bernardo-Filho M
Dept. de Biofísica e Biometria, Universidade do Estado do Rio de Janeiro, Brasil.
J Exp Clin Cancer Res. 1998 Mar;17(1):41-6.
Technetium-99m-labelled red blood cells (RBC) have been used as radiopharmaceutical in nuclear medicine. The influence of drug interaction in this labelling process has been described along with the biological effects of tobacco on the labelling of blood elements with technetium-99m. The labelling of RBC and plasma proteins can be decreased in presence of tobacco. This can be due to either a direct or indirect effect (reactive oxygen species) of tobacco by (i) oxidation of the stannous ion, (ii) possible damages caused in plasma membrane and/or (iii) possible chelating action on the stannous and/or pertechnetate ions.
锝-99m标记的红细胞（RBC）已被用作核医学中的放射性药物。本文描述了药物相互作用在该标记过程中的影响，以及烟草对用锝-99m标记血液成分的生物学效应。在烟草存在的情况下，红细胞和血浆蛋白的标记可能会减少。这可能是由于烟草的直接或间接作用（活性氧），通过（i）亚锡离子的氧化，（ii）对质膜可能造成的损害和/或（iii）对亚锡离子和/或高锝酸盐离子可能的螯合作用。
