Lewin K J, Dowling F, Wright J P, Taylor K B
Gut. 1976 Jul;17(7):551-60. doi: 10.1136/gut.17.7.551.
Mucosal biopsies from multiple sites in the stomachs of 21 patients with pernicious anaemia have been examined. The histological changes almost always involved the entire gastric mucosa, including that of the pyloric antrum. Metaplastic changes were almost universal and consisted of intestinal metaplasia in the body and antrum and pyloric metaplasia in the body. The severity of the pyloric metaplasia was such as to make the distinction between body and antrum on biopsy impossible. No relationship was found between serum gastrin activity and the histological appearances of the gastric antrum or body.
对21例恶性贫血患者胃部多个部位的黏膜活检样本进行了检查。组织学变化几乎总是累及整个胃黏膜，包括幽门窦黏膜。化生变化几乎普遍存在，包括胃体和胃窦的肠化生以及胃体的幽门化生。幽门化生的严重程度使得在活检时无法区分胃体和胃窦。未发现血清胃泌素活性与胃窦或胃体的组织学表现之间存在关联。
