Ejima E, Fujiyama K, Kiriyama T, Eguchi K
First Department of Internal Medicine, Nagasaki University School of Medicine.
Nihon Rinsho. 1998 Jun;56(6):1587-90.
Thyroid hormone (T3) is essential for normal bone growth and bone metabolism. T3 stimulates bone formation directly through T3 receptors in osteoblasts. T3 also stimulates bone resorption by osteoclasts probably secondary through osteoblasts. In thyrotoxicosis accelerated bone formation and resorption resulted in high turn-over bone loss. Bone metabolic markers elevate reflecting thyrotoxic state. Normalizing thyroid hormone level at least partially restore bone mineral content. In patients under thyroid hormone replacement therapy or TSH suppression therapy TSH and free thyroid hormones should be monitored to prevent unnecessary bone loss. Especially in postmenopausal women with thyrotoxicosis or thyroid hormone therapy the assessment of bone mineral content is required.
甲状腺激素（T3）对正常骨骼生长和骨代谢至关重要。T3通过成骨细胞中的T3受体直接刺激骨形成。T3还可能通过成骨细胞间接刺激破骨细胞的骨吸收。在甲状腺毒症中，加速的骨形成和吸收导致高转换型骨质流失。骨代谢标志物升高反映甲状腺毒症状态。使甲状腺激素水平正常化至少可部分恢复骨矿物质含量。在接受甲状腺激素替代治疗或促甲状腺激素抑制治疗的患者中，应监测促甲状腺激素和游离甲状腺激素，以防止不必要的骨质流失。特别是在患有甲状腺毒症或接受甲状腺激素治疗的绝经后女性中，需要评估骨矿物质含量。
