Tzung T Y, Rünger T M
Department of Dermatology, Georg August University of Göttingen, Germany.
Photochem Photobiol. 1998 Jun;67(6):647-50.
Phototherapy with broadband UVB is an effective treatment for inflammatory dermatoses. A newly developed fluorescent UVB lamp (Philips TL01) that emits a narrowband UVB around 311 nm was shown to be superior for the phototherapy of psoriasis. In order to contribute to the knowledge about the carcinogenic potential of this UVB source, we measured the DNA damage in lymphoblasts and keratinocytes induced by narrowband UVB and compared it with that by conventional broadband UVB using the single cell gel electrophoresis (comet assay). At equal doses, broadband UVB produced more DNA damage than narrowband UVB. However, in phototherapy of psoriasis, up to 10-fold higher doses are used with TL01. When therapeutically equivalent doses were compared (10-fold correction for narrowband UVB), we found only slight differences in the amount of DNA damage produced by broadband and narrowband UVB. This supports the already existing evidence that for phototherapy narrowband UVB is not more carcinogenic than broadband UVB.
宽带UVB光疗是治疗炎症性皮肤病的一种有效方法。一种新开发的荧光UVB灯（飞利浦TL01），其发射波长在311nm左右的窄带UVB，已被证明在银屑病光疗方面更具优势。为了增进对这种UVB光源致癌潜力的了解，我们使用单细胞凝胶电泳（彗星试验）测量了窄带UVB诱导的淋巴母细胞和角质形成细胞中的DNA损伤，并将其与传统宽带UVB诱导的DNA损伤进行比较。在相同剂量下，宽带UVB比窄带UVB产生更多的DNA损伤。然而，在银屑病光疗中，TL01使用的剂量比宽带UVB高10倍。当比较治疗等效剂量时（窄带UVB校正10倍），我们发现宽带和窄带UVB产生的DNA损伤量仅有细微差异。这支持了现有的证据，即对于光疗而言，窄带UVB并不比宽带UVB更具致癌性。
