Sugimoto S I, Takenaka K, Hirano K, Miyake Y, Imaizumi T
Department of Internal Medicine III, Kurume University School of Medicine, Japan.
Acta Physiol Scand. 1998 May;163(1):17-24. doi: 10.1046/j.1365-201x.1998.00340.x.
During exercise blood pressure fluctuates from minute to minute and does not rise linearly with time. Blood pressure responses were evaluated during exercise by a logistic function curve. Thirty-nine hypertensive patients underwent exercise testing with an ergometer, employing a multistage method (25 watts increment, every 3 min). We plotted the exercise duration on the X-coordinate and systolic blood pressure on the Y-coordinate and blood pressure was assumed to form a logistic curve for exercise duration. The relationship of systolic blood pressure vs. exercise duration was better fitted into a logistic function curve than a linear regression model. The logistic curve was defined by lower plateau, upper plateau, SPX (the X-coordinate at the shift point) and df (SPX), the maximal slope at the shift point. The effects of aging, gender and physical training were then analyzed on the curve. Aging did not affect lower plateau, upper plateau and SPX but augmented df (SPX), indicating greater blood pressure responses in older subjects during exercise. In females the curve was shifted to the left compared to males (SPX: 4.9 vs. 8.3 min, P < 0.05) without changes in plateaux and df (SPX), indicating greater blood pressure responses than males. Physical training for 3 weeks decreased the lower plateau from 157 to 144 mmHg (P < 0.05) and shifted the curve to the right (SPX: 7.1 vs. 8.6 min, P < 0.05), indicating unchanged blood pressure responses after training because of the opposite effects by decreases in the lower plateau vs. the curve shift to the right. In conclusion, blood pressure during exercise is better delineated by a logistic function curve than a linear regression model. The biological or physiological significance of df (SPX) is not clear at present and needs further investigations.
运动期间，血压每分钟都会波动，并非随时间呈线性上升。通过逻辑函数曲线评估运动期间的血压反应。39名高血压患者使用测力计进行运动测试，采用多级方法（每3分钟增加25瓦）。我们将运动持续时间绘制在X轴上，收缩压绘制在Y轴上，并假设血压随运动持续时间形成一条逻辑曲线。收缩压与运动持续时间的关系用逻辑函数曲线比线性回归模型拟合得更好。逻辑曲线由较低平台期、较高平台期、SPX（转折点处的X坐标）和df（SPX）（转折点处的最大斜率）定义。然后分析了年龄、性别和体育锻炼对该曲线的影响。年龄不影响较低平台期、较高平台期和SPX，但会增加df（SPX），表明老年受试者在运动期间血压反应更大。与男性相比，女性的曲线向左移动（SPX：4.9分钟对8.3分钟，P<0.05），平台期和df（SPX）无变化，表明女性的血压反应比男性更大。为期3周的体育锻炼使较低平台期从157 mmHg降至144 mmHg（P<0.05），并使曲线向右移动（SPX：7.1分钟对8.6分钟，P<0.05），这表明由于较低平台期降低与曲线向右移动的相反作用，训练后血压反应不变。总之，运动期间的血压用逻辑函数曲线比线性回归模型能更好地描绘。目前df（SPX）的生物学或生理学意义尚不清楚，需要进一步研究。
