炎症性肠病患者一级亲属中的抗中性粒细胞和胰腺自身抗体。
Antineutrophil and pancreatic autoantibodies in first-degree relatives of patients with inflammatory bowel disease.
作者信息
Folwaczny C, Noehl N, Endres S P, Loeschke K, Fricke H
机构信息
Medical Clinic, Klinikum Innenstadt, Ludwig-Maximilians Universität, Munich, Germany.
出版信息
Scand J Gastroenterol. 1998 May;33(5):523-8. doi: 10.1080/00365529850172106.
BACKGROUND
Perinuclear antineutrophil antibodies (P-ANCA) are found in ulcerative colitis, and autoantibodies against exocrine pancreas (PAB) in Crohn's disease. Their potential role as genetic or pathophysiologic factors is unclear.
METHODS
In 61 patients with ulcerative colitis, 76 patients with Crohn's disease, 101 first-degree relatives of patients with ulcerative colitis, 105 first-degree relatives of Crohn's disease patients, and 56 healthy unrelated controls autoantibodies were detected by indirect immunofluorescence.
RESULTS
Forty-six per cent of patients with ulcerative colitis (28 of 61) and 38% of patients with Crohn's disease (29 of 76) were P-ANCA- and PAB-positive, respectively. In relatives of patients with ulcerative colitis P-ANCA were found in 3% (3 of 101), and in relatives of Crohn's disease patients PAB were detected in 4% (4 of 105), which is not significantly different from the occurrence in the healthy controls.
CONCLUSIONS
The frequency of P-ANCA and PAB does not suggest a role as genetic markers for inflammatory bowel disease.
背景
核周型抗中性粒细胞抗体（P-ANCA）见于溃疡性结肠炎，而抗外分泌腺胰腺自身抗体（PAB）见于克罗恩病。它们作为遗传或病理生理因素的潜在作用尚不清楚。
方法
采用间接免疫荧光法检测61例溃疡性结肠炎患者、76例克罗恩病患者、101例溃疡性结肠炎患者的一级亲属、105例克罗恩病患者的一级亲属以及56名健康无关对照者的自身抗体。
结果
分别有46%的溃疡性结肠炎患者（61例中的28例）和38%的克罗恩病患者（76例中的29例）P-ANCA和PAB呈阳性。在溃疡性结肠炎患者的亲属中，3%（101例中的3例）检测到P-ANCA，在克罗恩病患者的亲属中，4%（105例中的4例）检测到PAB，这与健康对照者中的发生率无显著差异。
结论
P-ANCA和PAB的频率并不表明其作为炎症性肠病遗传标志物的作用。
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