Kobayashi S, Nitta S, Yambe T, Sonobe T, Naganuma S, Hashimoto H
Department of Medical Engineering and Cardiology, Tohoku University, Sendai, Japan.
Artif Organs. 1997 Jul;21(7):691-3. doi: 10.1111/j.1525-1594.1997.tb03724.x.
The vibrating flow pump (VFP) can generate high frequency oscillated blood flow. Because of the high frequency driving with short stroke volume, the pump system can be small. The disposable type VFP (D-VFP) was developed for use for extracorporeal circulation. The electromagnetic actuator was detached from the vibrating tube, which was newly designed to be a disposable tube with a jellyfish valve. Hemolysis tests of the D-VFP, VFP, centrifugal pump, and roller pump were performed in a mock circulation study using goat blood. Plasma free hemoglobin was measured every 15 min under the same conditions. The plasma free hemoglobin of the D-VFP was 16 mg/dl although that of the VFP was 160 mg/dl at 30 min. The plasma free hemoglobin of the centrifugal pump and roller pump at 30 min were 3 mg/dl and 9 mg/dl, respectively. The hemolysis performance of the D-VFP may be studied further as a result of this study. Two important factors affecting hemolysis development may be the materials of which the vibrating tube is made and heat transmission from the actuator. The D-VFP has a smooth acrylic surface for blood contact compared with the metal surface of old type VFP. The electromagnetic actuator of the VFP surrounded the vibrating tube, so heat from the actuator could be easily transmitted to the blood. Because the D-VFP has a disposable vibrating tube that is detached from the actuator, heat is not readily transmitted to the blood. A mock circulation study of heat transmission was performed using the D-VFP and VFP. Results of the heat transmission study showed that the fluid temperature of the D-VFP was not increased and stayed at room temperature although that of the VFP increased approximately 1 degree C above room temperature. The D-VFP may be a good style for the development of the VFP for use for extracorporeal circulation.
振动流泵（VFP）能够产生高频振荡血流。由于采用短冲程容积的高频驱动，泵系统可以做得很小。一次性使用的VFP（D-VFP）是为体外循环而开发的。电磁驱动器与振动管分离，新设计的振动管为带有水母阀的一次性管子。在一项使用山羊血液的模拟循环研究中，对D-VFP、VFP、离心泵和滚柱泵进行了溶血试验。在相同条件下，每隔15分钟测量一次血浆游离血红蛋白。D-VFP的血浆游离血红蛋白在30分钟时为16mg/dl，而VFP的为160mg/dl。离心泵和滚柱泵在30分钟时的血浆游离血红蛋白分别为3mg/dl和9mg/dl。基于本研究结果，D-VFP的溶血性能可能需要进一步研究。影响溶血发生的两个重要因素可能是振动管的制作材料以及驱动器的热传递。与老式VFP的金属表面相比，D-VFP具有用于血液接触的光滑丙烯酸表面。VFP的电磁驱动器围绕着振动管，因此驱动器产生的热量很容易传递到血液中。由于D-VFP有一个与驱动器分离的一次性振动管，热量不容易传递到血液中。使用D-VFP和VFP进行了热传递的模拟循环研究。热传递研究结果表明，D-VFP的流体温度没有升高，保持在室温，而VFP的流体温度比室温升高了约1摄氏度。D-VFP可能是用于体外循环的VFP开发的一种良好形式。
