一个细分群体中杂合位点的预期数量。
The expected number of heterozygous sites in a subdivided population.
作者信息
Nagylaki T
机构信息
Department of Ecology and Evolution, University of Chicago, Chicago, Illinois 60637, USA.
出版信息
Genetics. 1998 Jul;149(3):1599-604. doi: 10.1093/genetics/149.3.1599.
Abstract
A simple, exact formula is derived for the expected number of heterozygous sites per individual at equilibrium in a subdivided population. The model of infinitely many neutral sites is posited; the linkage map is arbitrary. The monoecious, diploid population is subdivided into a finite number of panmictic colonies that exchange gametes. The backward migration matrix is arbitrary, but time independent and ergodic (i.e., irreducible and aperiodic). With suitable weighting, the expected number of heterozygous sites is 4Neu, where Ne denotes the migration effective population number and u designates the total mutation rate per gene (or DNA sequence). For diploid migration, this formula is a good approximation if Ne >> 1.
摘要
推导出了一个简单、精确的公式，用于计算细分群体在平衡状态下每个个体杂合位点的预期数量。假定有无穷多个中性位点的模型；连锁图谱是任意的。雌雄同体的二倍体群体被细分为有限数量的随机交配群体，这些群体之间交换配子。向后迁移矩阵是任意的，但与时间无关且遍历（即不可约且非周期）。通过适当加权，杂合位点的预期数量为4Neu，其中Ne表示迁移有效群体数量，u表示每个基因（或DNA序列）的总突变率。对于二倍体迁移，如果Ne >> 1，该公式是一个很好的近似。
相似文献
1
The expected number of heterozygous sites in a subdivided population.一个细分群体中杂合位点的预期数量。
Genetics. 1998 Jul;149(3):1599-604. doi: 10.1093/genetics/149.3.1599.
2
Geographical invariance and the strong-migration limit in subdivided populations.细分种群中的地理不变性与强迁移极限
J Math Biol. 2000 Aug;41(2):123-42. doi: 10.1007/s002850070002.
3
The strong-migration limit in geographically structured populations.地理结构种群中的强迁移极限
J Math Biol. 1980 Apr;9(2):101-14. doi: 10.1007/BF00275916.
4
Homozygosity, effective number of alleles, and interdeme differentiation in subdivided populations.细分群体中的纯合性、等位基因有效数量及种群间分化
Proc Natl Acad Sci U S A. 1985 Dec;82(24):8611-3. doi: 10.1073/pnas.82.24.8611.
5
Patterns of multiallelic polymorphism maintained by migration and selection.由迁移和选择维持的多等位基因多态性模式。
Theor Popul Biol. 2001 Jun;59(4):297-313. doi: 10.1006/tpbi.2001.1526.
6
The influence of partial panmixia on neutral models of spatial variation.部分随机交配对空间变异中性模型的影响。
Theor Popul Biol. 2011 Feb-Mar;79(1-2):19-38. doi: 10.1016/j.tpb.2010.08.006. Epub 2010 Oct 1.
7
The influence of spatial inhomogeneities on neutral models of geographical variation IV. Discontinuities in the population density and migration rate.空间非均匀性对地理变异中性模型的影响IV. 种群密度和迁移率的不连续性
Theor Popul Biol. 1999 Dec;56(3):337-47. doi: 10.1006/tpbi.1999.1429.
8
Coalescent theory for a completely random mating monoecious population.完全随机交配雌雄同体种群的溯祖理论。
Math Biosci. 2007 Feb;205(2):315-24. doi: 10.1016/j.mbs.2006.08.002. Epub 2006 Aug 17.
9
The average number of sites separating DNA sequences drawn from a subdivided population.从一个细分群体中提取的DNA序列之间的平均间隔位点数量。
Theor Popul Biol. 1987 Aug;32(1):42-9. doi: 10.1016/0040-5809(87)90038-4.
10
Evolution under multiallelic migration-selection models.多等位基因迁移 - 选择模型下的进化
Theor Popul Biol. 2007 Aug;72(1):21-40. doi: 10.1016/j.tpb.2007.02.005. Epub 2007 Mar 18.
引用本文的文献
1
The effects of inversion polymorphisms on patterns of neutral genetic diversity.反转多态性对中性遗传多样性模式的影响。
Genetics. 2023 Aug 9;224(4). doi: 10.1093/genetics/iyad116.
2
Life history, climate and biogeography interactively affect worldwide genetic diversity of plant and animal populations.生物的生活史、气候和生物地理因素会相互影响，从而共同作用于世界各地动植物种群的遗传多样性。
Nat Commun. 2021 Jan 22;12(1):516. doi: 10.1038/s41467-021-20958-2.
3
Can secondary contact following range expansion be distinguished from barriers to gene flow?在范围扩张后的二次接触能否与基因流动障碍区分开来？
PeerJ. 2018 Oct 1;6:e5325. doi: 10.7717/peerj.5325. eCollection 2018.
4
Regional and local patterns of genetic variation and structure in yellow-necked mice - the roles of geographic distance, population abundance, and winter severity.黄颈鼠遗传变异与结构的区域和局部模式——地理距离、种群丰度和冬季严酷程度的作用
Ecol Evol. 2018 Jul 22;8(16):8171-8186. doi: 10.1002/ece3.4291. eCollection 2018 Aug.
5
Estimating Barriers to Gene Flow from Distorted Isolation-by-Distance Patterns.估计由偏离的隔离-距离模式引起的基因流障碍。
Genetics. 2018 Mar;208(3):1231-1245. doi: 10.1534/genetics.117.300638. Epub 2018 Jan 8.
6
On the Recombination Rate Estimation in the Presence of Population Substructure.关于存在群体亚结构时的重组率估计
PLoS One. 2015 Dec 30;10(12):e0145152. doi: 10.1371/journal.pone.0145152. eCollection 2015.
7
Footprints of ancient-balanced polymorphisms in genetic variation data from closely related species.来自近缘物种遗传变异数据中古代平衡多态性的印记。
Evolution. 2015 Feb;69(2):431-46. doi: 10.1111/evo.12567. Epub 2015 Jan 16.
8
Stochastic demography and the neutral substitution rate in class-structured populations.阶层结构种群中的随机人口统计学与中性替代率
Genetics. 2014 May;197(1):351-60. doi: 10.1534/genetics.114.163345. Epub 2014 Mar 3.
9
Temporal variation in population size of European bird species: effects of latitude and marginality of distribution.欧洲鸟类物种种群数量的时间变化：纬度和分布边缘性的影响。
PLoS One. 2013 Oct 17;8(10):e77654. doi: 10.1371/journal.pone.0077654. eCollection 2013.
10
Quasi equilibrium, variance effective size and fixation index for populations with substructure.具有亚结构种群的准平衡、方差有效大小和固定指数。
J Math Biol. 2014 Nov;69(5):1057-128. doi: 10.1007/s00285-013-0728-9. Epub 2013 Oct 15.
本文引用的文献
1
Average number of nucleotide differences in a sample from a single subpopulation: a test for population subdivision.样本中单一个体群的核苷酸差异平均数：群体划分的检验。
Genetics. 1987 Sep;117(1):149-53. doi: 10.1093/genetics/117.1.149.
2
The number of segregating sites in a sample of DNA sequences from a geographically structured population.来自具有地理结构的种群的DNA序列样本中的分离位点数量。
J Math Biol. 1997 Dec;36(2):188-200. doi: 10.1007/s002850050097.
3
Structured coalescent processes on different time scales.不同时间尺度上的结构化合并过程。
Genetics. 1997 Aug;146(4):1501-14. doi: 10.1093/genetics/146.4.1501.
4
Effective size and F-statistics of subdivided populations. II. Dioecious species.细分种群的有效大小和F统计量。II. 雌雄异株物种。
Genetics. 1997 Aug;146(4):1465-74. doi: 10.1093/genetics/146.4.1465.
5
Effective size and F-statistics of subdivided populations. I. Monoecious species with partial selfing.细分种群的有效大小和F统计量。I. 具有部分自交的雌雄同株物种。
Genetics. 1997 Aug;146(4):1453-63. doi: 10.1093/genetics/146.4.1453.
6
The effective size of a subdivided population.一个细分种群的有效大小。
Genetics. 1997 May;146(1):427-41. doi: 10.1093/genetics/146.1.427.
7
The coalescent in two colonies with symmetric migration.具有对称迁移的两个群体中的溯祖过程
J Math Biol. 1993;31(8):841-51. doi: 10.1007/BF00168049.
8
Effective population size, genetic diversity, and coalescence time in subdivided populations.细分种群中的有效种群大小、遗传多样性和溯祖时间。
J Mol Evol. 1993 Sep;37(3):240-4. doi: 10.1007/BF00175500.
9
Geographical variation in a quantitative character.数量性状的地理变异
Genetics. 1994 Jan;136(1):361-81. doi: 10.1093/genetics/136.1.361.
10
Developments in the prediction of effective population size.有效种群大小预测的进展。
Heredity (Edinb). 1994 Dec;73 ( Pt 6):657-79. doi: 10.1038/hdy.1994.174.
Zotero 插件