Reis M D, Tellechea O, Baptista A P
Clínica Dermatológica Universitária de Lisboa, Hospital de Santa Maria, Av. Prof. Egas Moniz, 1699 Lisboa Codex, Portugal.
Eur J Dermatol. 1998 Apr-May;8(3):186-8.
A verrucous cyst is an unusual, histopathologically distinctive, epidermoid cyst characterised by verrucous changes in its wall. We report two cases of verrucous cysts in different patients, one on the back and the other on the cheek. Clinically, the lesions were thought to represent an epidermoid cyst and a basal cell carcinoma, respectively. Histologically, we found in both cases an intradermal epidermoid cyst lined by a stratified squamous epithelium with focal cytopathogenic viral changes, consisting of papillomatosis, ortho- and parakeratosis, and hypergranulosis. One case also showed, within the squamous areas of the hyperplastic epithelium, occasional squamous eddies. These histopathological features support the diagnosis of verrucous cyst, which may represent a manifestation of human papillomavirus infection. This virus may induce cyst formation or just infect a pre-existing one.
疣状囊肿是一种不常见的、组织病理学上具有独特性的表皮样囊肿，其特征是囊壁有疣状改变。我们报告了两例分别发生在不同患者身上的疣状囊肿，一例位于背部，另一例位于脸颊。临床上，这些病变分别被认为是表皮样囊肿和基底细胞癌。组织学上，我们在两例中均发现真皮内表皮样囊肿，内衬复层鳞状上皮，伴有局灶性细胞致病性病毒改变，包括乳头瘤病、正角化和不全角化以及颗粒层增厚。其中一例在增生上皮的鳞状区域内还可见偶尔的鳞状漩涡。这些组织病理学特征支持疣状囊肿的诊断，疣状囊肿可能是人类乳头瘤病毒感染的一种表现。这种病毒可能诱发囊肿形成，也可能只是感染已有的囊肿。
