Kim Haeryoung, Seok Jae Yeon, Kim Se Hoon, Cho Nam Hoon, Chung Won Soon, Hann Seung-Kyung, Lee Kwang Gil
Department of Pathology, Yonsei University College of Medicine, Seodaemun-gu, Seoul, Korea.
Eur J Dermatol. 2006 May-Jun;16(3):254-7.
The verrucous cyst is a non-plantar epidermoid cyst with histopathological features of human papillomavirus (HPV) infection, including papillomatosis and hypergranulosis of the cyst lining. We report the first case of a verrucous cyst demonstrating not only the histopathological and immunohistochemical features of HPV infection, but also homology with HPV type 59 on HPV genotyping. A 28-year-old male developed a palpable mass in his right flank. Histological examination revealed an intradermal cyst lined by an acanthotic and papillomatous squamous epithelium with prominent keratohyaline granules and squamous eddies. The keratinocyte nuclei were positive for papillomavirus antigens on immunohistochemistry and HPV genotyping demonstrated a homology to HPV type 59, a high-risk genital type. Although we only experienced a single case with such a finding, we suggest that it may be necessary to subject patients with verrucous cysts to a closer follow up for better characterization of their clinical behavior.
疣状囊肿是一种非足底表皮样囊肿，具有人乳头瘤病毒（HPV）感染的组织病理学特征，包括囊肿内衬的乳头瘤病和颗粒层增厚。我们报告了首例疣状囊肿病例，该病例不仅显示了HPV感染的组织病理学和免疫组化特征，而且在HPV基因分型上与59型HPV具有同源性。一名28岁男性右侧胁腹出现一个可触及的肿块。组织学检查显示为一个皮内囊肿，内衬棘皮样和乳头瘤样鳞状上皮，有明显的透明角质颗粒和鳞状漩涡。免疫组化显示角质形成细胞核乳头瘤病毒抗原呈阳性，HPV基因分型显示与59型HPV同源，59型为高危生殖器型。尽管我们仅遇到一例这样的病例，但我们建议，对于疣状囊肿患者，可能有必要进行更密切的随访，以更好地了解其临床行为特征。
