Meyer L M, Tyring S K, Little W P
Department of Pathology, University of Alabama, Birmingham.
Arch Dermatol. 1991 Dec;127(12):1810-2.
Human papillomavirus has been detected in a variety of cutaneous premalignant and malignant conditions, as well as in benign cutaneous warts. Changes consistent with epidermis papilloma virus infection occurring in epidermal cysts have recently been reported in the dermatologic literature only in plantar epidermal cysts. We report five examples of a form of cutaneous cyst that is histologically distinctive and that has not been previously reported, to our knowledge. We describe five cases of epidermal cysts showing marked verrucous changes of their stratified squamous inner linings, some of which also show proliferative changes. Human papillomavirus genomes were detected via polymerase chain reaction. None of the DNA probes for Southern blot hybridization demonstrated homology with the human papillomavirus types usually associated with cutaneous warts or carcinoma. We believe this cyst to represent a newly described manifestation of human papillomavirus infection, and propose the name verrucous cyst for this entity. Further studies may reveal the specific human papillomavirus type(s) associated with the verrucous cyst.
人类乳头瘤病毒已在多种皮肤癌前病变和恶性病变以及良性皮肤疣中被检测到。最近，皮肤病学文献中仅报道了足底表皮囊肿中出现与表皮乳头状瘤病毒感染一致的变化。据我们所知，我们报告了五例组织学上具有独特特征且此前未被报道过的皮肤囊肿。我们描述了五例表皮囊肿，其分层鳞状内衬显示出明显的疣状变化，其中一些还表现出增殖性变化。通过聚合酶链反应检测到人类乳头瘤病毒基因组。Southern印迹杂交的DNA探针均未显示与通常与皮肤疣或癌相关的人类乳头瘤病毒类型具有同源性。我们认为这种囊肿代表了人类乳头瘤病毒感染的一种新描述表现，并为此实体提出疣状囊肿这一名称。进一步的研究可能会揭示与疣状囊肿相关的特定人类乳头瘤病毒类型。
