Holst R G, Kristofferson A
Department of Dermatology, Malmö University Hospital, MAS, SE-214 01 Malmö, Sweden.
Eur J Dermatol. 1998 Jun;8(4):245-7.
Pain prevents the effective cleansing of many leg ulcers. Pain relief during debridement has been reported after topical anaesthesia with EMLA cream. The purpose of this study was to assess and compare the pain intensity during debridement after different lengths of application time of EMLA. Fifty-nine patients, stratified for leg ulcer type, were randomised to 10, 20 or 60 minutes treatment with EMLA prior to debridement. The pain was rated by each patient on a 100-mm visual analogue scale (VAS). Pain intensity during debridement decreased significantly with increasing duration of EMLA application (p = 0.001). The median values of the VAS pain scores were 41, 20 and 8 in the 10-, 20- and 60- minute groups respectively. A minimum of 20 minutes application time gives substantial pain relief in the majority of patients.
疼痛会妨碍许多腿部溃疡的有效清创。据报道，使用EMLA乳膏进行局部麻醉后，清创过程中的疼痛得到缓解。本研究的目的是评估和比较在不同应用时间长度的EMLA后清创过程中的疼痛强度。59例患者根据腿部溃疡类型进行分层，在清创前随机接受10、20或60分钟的EMLA治疗。每位患者使用100毫米视觉模拟量表（VAS）对疼痛进行评分。随着EMLA应用时间的增加，清创过程中的疼痛强度显著降低（p = 0.001）。10分钟、20分钟和60分钟组的VAS疼痛评分中位数分别为41、20和8。至少20分钟的应用时间能使大多数患者的疼痛得到显著缓解。
