Willis C M, Reiche L, Wilkinson J D
Department of Dermatology, Amersham Hospital, Whielden Street, Amersham, Bucks, HP7 0JD, UK.
Eur J Dermatol. 1998 Jan-Feb;8(1):8-12.
Oxidative stress is known to be implicated in the inflammation induced by the anti-psoriatic irritant, dithranol. In this study, we wished to investigate whether this is reflected in the levels of the antioxidant enzyme, Cu,Zn-superoxide dismutase, as detected by quantitative immunocytochemistry, and whether similar changes also occur following exposure to an irritant not normally associated with reactive oxygen species generation, namely sodium lauryl sulphate. Analysis of biopsies from patch test sites revealed that significant reductions in the epidermal levels of Cu,Zn-superoxide dismutase were induced by both dithranol and sodium lauryl sulphate, although the time course of diminished activity was different for each irritant. Our findings suggest that oxidative stress plays a general role in the pathophysiology of acute irritant contact dermatitis.
已知氧化应激与抗银屑病刺激物地蒽酚所引发的炎症有关。在本研究中，我们希望探究这是否反映在通过定量免疫细胞化学检测到的抗氧化酶铜锌超氧化物歧化酶的水平上，以及在接触通常与活性氧生成无关的刺激物（即十二烷基硫酸钠）后是否也会发生类似变化。对斑贴试验部位活检组织的分析表明，地蒽酚和十二烷基硫酸钠均可导致表皮中铜锌超氧化物歧化酶水平显著降低，尽管每种刺激物活性降低的时间进程有所不同。我们的研究结果表明，氧化应激在急性刺激性接触性皮炎的病理生理学中起普遍作用。
