Ikonen S, Schmidt B, Riekkinen P
Department of Neuroscience and Neurology, University of Kuopio, Finland.
Eur J Pharmacol. 1998 Apr 17;347(1):13-21. doi: 10.1016/s0014-2999(98)00075-2.
We investigated the effects of acute i.p. injections of the Ca2+-dependent K+ channel blocker, apamin, on water maze spatial navigation, Y-maze and passive avoidance behavior in intact and medial septal-lesioned mice. Apamin 0.02, 0.06 or 0.2 mg/kg (i.p.) administered 30 min before or immediately after the training did not affect the performance of intact mice. Apamin 0.02 or 0.06 mg/kg (i.p.) administered immediately after the daily training did not affect the performance of medial septal-lesioned mice. Apamin 0.02 and 0.06 mg/kg (i.p.) administered 30 min before daily training reversed the navigation failure present in medial septal-lesioned mice during the initial and reversal learning stages of the water maze task. Apamin had no effect on the cognitive performance in Y-maze or passive avoidance tests. The results indicate that blockade of Ca2+-dependent K+ channels may facilitate acquisition of spatial navigation performance, but has no effect on consolidation, inhibitory avoidance and spontaneous alternation behavior in mice.
我们研究了腹腔注射Ca2+依赖性钾通道阻滞剂蜂毒明肽对完整小鼠和内侧隔区损伤小鼠的水迷宫空间导航、Y迷宫及被动回避行为的影响。在训练前30分钟或训练后立即腹腔注射0.02、0.06或0.2 mg/kg的蜂毒明肽，对完整小鼠的行为表现没有影响。每日训练后立即腹腔注射0.02或0.06 mg/kg的蜂毒明肽，对内侧隔区损伤小鼠的行为表现没有影响。在每日训练前30分钟腹腔注射0.02和0.06 mg/kg的蜂毒明肽，可逆转内侧隔区损伤小鼠在水迷宫任务初始和反转学习阶段出现的导航障碍。蜂毒明肽对Y迷宫或被动回避测试中的认知表现没有影响。结果表明，阻断Ca2+依赖性钾通道可能有助于获得空间导航能力，但对小鼠的巩固、抑制性回避和自发交替行为没有影响。
