Chand N, Carlson H C, Eyre P
Int Arch Allergy Appl Immunol. 1976;51(4):508-17. doi: 10.1159/000231624.
Passive cutaneous anaphylaxis (PCA) has been demonstrated in young and adult domestic fowl using antisera obtained from actively sensitized chickens on the day of their maximal susceptibility to systemic anaphylaxis. Young chickens are more sensitive to histamine and PCA reaction than adults. The PCA reaction was inhibited by the H1-histamine receptor blocker, mepyramine. In the PCA reaction of 2 h sensitization period, the main exudating cells were heterophils, mononuclear cells (lymphocytes, monocytes and macrophages) and some basophils. This study suggests a possible role for circulating basophils in the mediation of early acute inflammatory reaction of immunological origin.
被动皮肤过敏反应（PCA）已在幼年和成年家禽中得到证实，所用抗血清取自对全身过敏反应具有最大易感性之日的主动致敏鸡。幼鸡比成年鸡对组胺和PCA反应更敏感。PCA反应被H1组胺受体阻滞剂美吡拉敏抑制。在致敏期为2小时的PCA反应中，主要渗出细胞为嗜异性粒细胞、单核细胞（淋巴细胞、单核细胞和巨噬细胞）以及一些嗜碱性粒细胞。本研究表明循环嗜碱性粒细胞在免疫源性早期急性炎症反应的介导中可能发挥作用。
