Garside P, Ingulli E, Merica R R, Johnson J G, Noelle R J, Jenkins M K
University of Glasgow, Department of Immunology, Western Infirmary, Glasgow, G11 6NT, United Kingdom.
Science. 1998 Jul 3;281(5373):96-9. doi: 10.1126/science.281.5373.96.
Early events in the humoral immune response were visualized in lymph nodes by simultaneous tracking of antigen-specific CD4 T and B cells after immunization. The T cells were initially activated in the T cell areas when the B cells were still randomly dispersed in the B cell-rich follicles. Both populations then migrated to the edges of the follicles and interacted there, resulting in CD154-dependent B cell proliferation and germinal center formation. These results provide visual documentation of cognate T-B cell interactions and localize them to the follicular border.
通过免疫后同时追踪抗原特异性CD4 T细胞和B细胞，在淋巴结中观察到体液免疫反应的早期事件。当B细胞仍随机分散在富含B细胞的滤泡中时，T细胞最初在T细胞区被激活。然后这两种细胞群体都迁移到滤泡边缘并在那里相互作用，导致依赖CD154的B细胞增殖和生发中心形成。这些结果提供了同源T-B细胞相互作用的直观记录，并将它们定位到滤泡边界。
