Hohenegger M, Holzer F
Int J Clin Pharmacol Biopharm. 1976 Jun;13(4):298-303.
The effects of X and T in different doses alone or in combination on renal sodium and potassium excretion were examined in conscious rats. In acute experiments, the combination of both diuretics produced an approximately additive effect on sodium excretion. Addition of T to X in different dose relations (X:T = 1:0.5, 1:1 or 1:1.5) prevented the X-induced potassium loss. These effects were more pronounced at the highest dose of T; the difference to the other combinations, however, was small. In chronic experiments, when the diuretics were administered daily for 13 days, both combinations (X:T = 1:1 and X:T = 1:1.5) resulted in a nearly equilibrated potassium balance at the end of this period. In shorter intervals, however, sometimes considerable oscillations in potassium excretion occured.
在清醒大鼠中研究了不同剂量的X和T单独或联合使用对肾钠和钾排泄的影响。在急性实验中，两种利尿剂联合使用对钠排泄产生了近似相加的作用。以不同剂量比例（X:T = 1:0.5、1:1或1:1.5）将T添加到X中可防止X诱导的钾流失。这些作用在T的最高剂量时更为明显；然而，与其他组合的差异很小。在慢性实验中，当利尿剂每日给药13天时，两种组合（X:T = 1:1和X:T = 1:1.5）在此期间结束时导致钾平衡几乎达到平衡。然而，在较短的时间间隔内，钾排泄有时会出现相当大的波动。
