Asmathbanu I, Kaliwal B B
Department of Studies in Zoology, Karnatak University, India.
J Basic Clin Physiol Pharmacol. 1997;8(4):237-54. doi: 10.1515/jbcpp.1997.8.4.237.
Methyl parathion, an organophosphorus pesticide, was administered i.p. at a dose of 5 mg/kg body weight to hemicastrated virgin rats for 1, 5, 10 and 15 days. Treatment with methyl parathion for 1 and 5 days revealed no change in the ovarian weight with -0.64% and -9.63% hypertrophy respectively and no change in healthy and atretic follicles when compared with hemicastrated oil-treated controls. However, treatment with methyl parathion for 10 and 15 days resulted in a significant decrease in ovarian weight gain with -21.36% and -31.98% hypertrophy, respectively, a significant decrease in the number of healthy follicles, and no change in the number of atretic follicles. The number of estrous cycles and duration of each phase of the estrous cycle were significantly affected with methyl parathion treatment for 5, 10 and 15 days. However, there were no significant changes in the number of estrous cycles and duration of estrus and metestrus phases in 1 day methyl parathion treatment except for a decrease and increase in proestrus and diestrus phases respectively. The weight of the uterus was significantly decreased whereas those of the liver, kidney and adrenal did not change in any of the methyl parathion treated groups.
对半阉割的未交配雌性大鼠腹腔注射甲基对硫磷（一种有机磷农药），剂量为5毫克/千克体重，持续1、5、10和15天。甲基对硫磷处理1天和5天，卵巢重量分别有-0.64%和-9.63%的增大，与半阉割并经油处理的对照组相比，健康卵泡和闭锁卵泡数量均无变化。然而，甲基对硫磷处理10天和15天导致卵巢重量增加显著降低，分别为-21.36%和-31.98%的增大，健康卵泡数量显著减少，闭锁卵泡数量无变化。甲基对硫磷处理5天、10天和15天对发情周期数和发情周期各阶段的持续时间有显著影响。然而，甲基对硫磷处理1天，除了发情前期减少和动情后期增加外，发情周期数以及发情期和动情后期的持续时间均无显著变化。子宫重量显著降低，而在任何甲基对硫磷处理组中，肝脏、肾脏和肾上腺的重量均无变化。
