局部用新霉素致聋（作者译）
[Deafness due to topical neomycin (author's transl)].
作者信息
Quante M
出版信息
HNO. 1976 Apr;24(4):127-8.
PMID:965261
Abstract
Today neomycin is almost exclusively given as an ointment in combination with other antibiotics, because of its known oto- and nephrotoxicity. Topical application in high dosage can cause ototoxicity as proved by one patient from this clinic. After laryngectomy and neck dissection for an extensive carcinoma of the epiglottis a 2 X 2 cm dehiscent pyocyaneus infected wound was treated daily with neomycin sulphate solution. A total of 30 gm was given over 3 months during which time the patient became deaf neomycin caused the deafness.
摘要
由于新霉素已知的耳毒性和肾毒性，如今它几乎仅作为软膏与其他抗生素联合使用。正如本诊所的一名患者所证实的，高剂量局部应用会导致耳毒性。在因广泛的会厌癌行喉切除及颈部清扫术后，一个2×2厘米的铜绿假单胞菌感染裂开伤口每天用硫酸新霉素溶液治疗。在3个月内共给予了30克，在此期间患者失聪，是新霉素导致了耳聋。
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