Goldman D
Psychopharmacology (Berl). 1976 Jun 23;47(3):271-2. doi: 10.1007/BF00427612.
Previous experience indicated the possibility that a serotonin antagonist substance, was effective in relieving dyskinesia as a reaction to phenothiazine antipsychotic drugs. Since the substances used in the original observations did not become available on the United States market, a compound known to be a serotonin antagonist, cyproheptadine, which was readily available and safe, was used to treat three patients who had phenothiazine-induced dyskinesia. In these patients, cyproheptadine was definitely effective in relieving the dyskinesia over an extended period of time. Further controlled studies are required to confirm this report.
以往的经验表明，一种血清素拮抗剂物质有可能有效缓解因使用吩噻嗪类抗精神病药物而产生的运动障碍。由于最初观察中使用的物质在美国市场上无法获得，一种已知为血清素拮抗剂且容易获得且安全的化合物——赛庚啶，被用于治疗三名患有吩噻嗪诱导性运动障碍的患者。在这些患者中，赛庚啶在较长一段时间内确实有效地缓解了运动障碍。需要进一步的对照研究来证实本报告。
