Paxton W A, Kang S
Department of Human Retrovirology, Academic Medical Center, Meibergdreef 15, Amsterdam, 1105 AZ, The Netherlands.
Semin Immunol. 1998 Jun;10(3):187-94. doi: 10.1006/smim.1998.0132.
It is now well established that an array of CC and CXC chemokine receptors, in association with the CD4 molecule, can interact with the HIV-1 gp120 protein to facilitate viral fusion. A 32bp deletion in the CC chemokine receptor CCR5, the major M-tropic viral co-receptor, provides considerable protection against HIV-1 transmission and has been associated with a delay in disease progression. The effects of the Delta32 allele appear to be mediated through the phenotype of CCR5 expression as opposed to genotype. Here we discuss the potential effects that the Delta32 allele and other polymorphisms in the chemokine receptor repertoire may have on both HIV-1 transmission and disease progression.
现已明确，一系列CC和CXC趋化因子受体与CD4分子结合后，可与HIV-1 gp120蛋白相互作用，促进病毒融合。CC趋化因子受体CCR5（主要的M嗜性病毒共受体）中的一个32bp缺失，为抵抗HIV-1传播提供了相当大的保护作用，并与疾病进展延迟相关。Delta32等位基因的作用似乎是通过CCR5表达的表型介导的，而非基因型。在此，我们讨论Delta32等位基因及趋化因子受体库中的其他多态性可能对HIV-1传播和疾病进展产生的潜在影响。
