人体颈动脉压力反射反应性的调节：姿势和普萘洛尔的影响。

Modulation of carotid baroreflex responsiveness in man: effects of posture and propranolol.

作者信息

Eckberg D L, Abboud F M, Mark A L

出版信息

J Appl Physiol. 1976 Sep;41(3):383-7. doi: 10.1152/jappl.1976.41.3.383.

DOI:10.1152/jappl.1976.41.3.383

Abstract

Carotid baroreceptors were stimulated with graded neck suction in supine and standing volunteers, before and after autonomic blockade, to determine the influence of posture on baroreflex responsiveness. Propranolol significantly augmented baroreflex pulse interval prolongation in the supine position. Upright posture did not modify baroreflex pulse interval responses prior to propranolol, but significantly augmented responses after propranolol. The results suggest that standing enhances baroreflex sensitivity, but that under normal circumstances, this effect is masked by beta-adrenergic stimulation. Augmentation of baroreflex pulse interval prolongation in the supine and standing positions by propranolol may contribute to the effectiveness of this drug in angina pectoris and labile hypertension.

摘要

在自主神经阻滞前后，对仰卧位和站立位的志愿者进行分级颈部吸引，以刺激颈动脉压力感受器，从而确定姿势对压力反射反应性的影响。普萘洛尔显著增强了仰卧位时压力反射性脉搏间期的延长。在使用普萘洛尔之前，直立姿势并未改变压力反射性脉搏间期反应，但在使用普萘洛尔后显著增强了反应。结果表明，站立可增强压力反射敏感性，但在正常情况下，这种作用被β-肾上腺素能刺激所掩盖。普萘洛尔在仰卧位和站立位增强压力反射性脉搏间期延长，可能有助于该药物在心绞痛和不稳定型高血压治疗中的有效性。