普萘洛尔用药前后对颈动脉窦刺激的反应。
Responses to carotid sinus stimulation before and after propranolol.
作者信息
Berglund H, Rosenqvist M, Boukter S, Bevegård S, Edhag K O
机构信息
Department of Medicine, Karolinska Institute, Huddinge Hospital, Stockholm, Sweden.
出版信息
Br Heart J. 1988 Dec;60(6):516-21. doi: 10.1136/hrt.60.6.516.
The response to carotid sinus stimulation was studied in nine elderly men (mean age 67) with no history of cardiac disease, dizziness, or syncope. The response to manual carotid sinus pressure (during one of two studies) was positive (an RR interval of greater than 3s) in three men. But seven men showed positive responses after intravenous propranolol (0.1 mg/kg). Similarly, the RR interval was lengthened by greater than 10 ms/mm Hg in two men during neck suction. Neck suction produced a positive result in four men after intravenous propranolol. The detection of hypersensitivity of the carotid sinus in a high proportion of apparently healthy men, especially during beta blockade, suggests that an abnormal response to carotid sinus massage may not be a reliable indicator for pacemaker treatment.
对9名无心脏病、头晕或晕厥病史的老年男性（平均年龄67岁）进行了颈动脉窦刺激反应的研究。在两项研究中的一项期间，对3名男性进行手动颈动脉窦按压时反应为阳性（RR间期大于3秒）。但7名男性在静脉注射普萘洛尔（0.1mg/kg）后出现阳性反应。同样，在颈部吸引期间，两名男性的RR间期每毫米汞柱延长超过10毫秒。静脉注射普萘洛尔后，颈部吸引在4名男性中产生了阳性结果。在相当比例的看似健康的男性中检测到颈动脉窦过敏，尤其是在β受体阻滞剂治疗期间，这表明对颈动脉窦按摩的异常反应可能不是起搏器治疗的可靠指标。
Zotero 插件