Olej B, dos Santos N F, Leal L, Rumjanek V M
Departamento de Bioquímica Médica, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Brazil.
Biosci Rep. 1998 Feb;18(1):1-7. doi: 10.1023/a:1022259832207.
Apoptotic cell death plays a critical role in immune system homeostasis, and c-myc protooncogene deregulated expression is a component of this programmed genomic response. Pharmacological intervention and modulation of peripheral lymphocytes apoptosis would have important implications. The present results indicate that ouabain, a specific inhibitor of Na+K(+)-ATPase, promotes an increased expression of c-myc mRNA, and induces apoptosis in PHA-stimulated lymphocytes. Furthermore, this ouabain-induced apoptosis cannot be counteracted by the addition of exogenous IL-2.
凋亡性细胞死亡在免疫系统稳态中起关键作用，而c-myc原癌基因的失调表达是这种程序性基因组反应的一个组成部分。对外周淋巴细胞凋亡进行药理干预和调节具有重要意义。目前的结果表明，哇巴因（一种Na+K(+)-ATP酶的特异性抑制剂）可促进c-myc mRNA表达增加，并诱导PHA刺激的淋巴细胞凋亡。此外，添加外源性IL-2并不能抵消这种哇巴因诱导的凋亡。
