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Effect of dietary n-3 fatty acids on interleukin-2 and interleukin-2 receptor alpha expression in activated murine lymphocytes.

作者信息

Jolly C A, McMurray D N, Chapkin R S

机构信息

Faculty of Nutrition and Molecular and Cell Biology Group, Texas A&M University, College Station 77843-2471, USA.

出版信息

Prostaglandins Leukot Essent Fatty Acids. 1998 Apr;58(4):289-93. doi: 10.1016/s0952-3278(98)90038-2.

DOI:10.1016/s0952-3278(98)90038-2
PMID:9654402
Abstract

Dietary eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) suppress interleukin-2 (IL-2) secretion and impair T-lymphocyte proliferation. To determine the mechanism of action, mice were fed diets containing either safflower oil (control diet enriched in linoleic acid, 18:2n-6), EPA, DHA or arachidonic acid (20:4n-6). Splenic lymphocytes were isolated and concanavalin A-induced kinetics of IL-2 and IL-2 receptor alpha mRNA expression were determined by relative competitive-PCR. EPA and DHA did not affect IL-2 mRNA expression but suppressed IL-2 receptor alpha mRNA levels. These data show, for the first time, the selective effects of dietary EPA and DHA on T-lymphocyte gene expression.

摘要

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