黑曲霉对白芒苔二醇二乙酸酯、白芒苔-4(15)-烯-9-酮和白芒苔醇的生物转化

Biotransformation of shiromodiol diacetate, myli-4(15)-en-9-one and myliol by Aspergillus niger.

作者信息

Hayashi K, Asano K, Tanaka M, Takaoka D, Nozaki H

机构信息

Department of Biochemistry, Faculty of Science, Okayama University of Science, Japan.

出版信息

Phytochemistry. 1998 Jun;48(3):461-6. doi: 10.1016/s0031-9422(97)00895-9.

DOI:10.1016/s0031-9422(97)00895-9

PMID:9654775

Abstract

Microbiol biotransformation of shiromodiol diacetate from Neolitsea serisea koids, and of myli-4(15)-en-9-one and myliol from the liverwort Mylia taylorii, were carried out with Aspergillus niger IFO 4407. A. niger hydroxylated the allyl position (C-2) of shiromodiol diacetate, and one of the geminal dimethyl groups of myli-4(15)-en-9-one and myliol regioselectively. The structures of these transformants were elucidated by spectral analysis and confirmed by X-ray analysis.

摘要

利用黑曲霉IFO 4407对新木姜子中的白木二醇二乙酸酯以及地钱中的迈立-4(15)-烯-9-酮和迈立醇进行微生物生物转化。黑曲霉对白木二醇二乙酸酯的烯丙基位置（C-2）以及迈立-4(15)-烯-9-酮和迈立醇的偕二甲基之一进行区域选择性羟基化。通过光谱分析阐明了这些转化产物的结构，并通过X射线分析进行了确认。