血小板第4因子对嗜中性粒细胞和单核细胞具有趋化作用。
Platelet factor 4 is chemotactic for neutrophils and monocytes.
作者信息
Deuel T F, Senior R M, Chang D, Griffin G L, Heinrikson R L, Kaiser E T
出版信息
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4584-7. doi: 10.1073/pnas.78.7.4584.
Abstract
Platelet factor 4 is shown to be a chemotactic protein for human polymorphonuclear leukocytes and monocytes at concentrations found in human serum and reached locally in injured tissue. The maximum chemotactic response to platelet factor 4 nearly equals that achieved with saturating concentrations of the chemotactic activity derived from the fifth component of human complement, C5. Cells desensitized to C5 chemotactic activity retain chemotactic responsiveness to platelet factor 4. Serum contains inhibitory capacity against the chemotactic activity associated with platelet factor 4. Our results suggest that the local release of platelet factor 4 may be an important stimulus attracting inflammatory cells to sites of blood vessel injury.
摘要
血小板第4因子在人血清中的浓度以及在受伤组织局部所达到的浓度下，被证明是一种对人多形核白细胞和单核细胞具有趋化作用的蛋白质。对血小板第4因子的最大趋化反应几乎等同于用人补体第五成分C5的趋化活性饱和浓度所获得的反应。对C5趋化活性脱敏的细胞对血小板第4因子仍保持趋化反应性。血清含有针对与血小板第4因子相关的趋化活性的抑制能力。我们的结果提示，血小板第4因子的局部释放可能是吸引炎症细胞至血管损伤部位的一个重要刺激因素。
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