Loesche W J
University of Michigan School of Dentistry, Department of Biologic and Material Sciences, Ann Arbor 48109, USA.
Curr Opin Periodontol. 1997;4:21-8.
Recently, there have been case-control and epidemiologic investigations that strongly associate poor dental health with cardiovascular disease, preterm low birth weight infants, and early death from any cause. In a 7-year prospective study, dental disease was a significant predictor of coronary events leading to death after controlling for known coronary disease risk factors. Missing teeth displaces smoking as a risk factor for ischemic heart disease in another study. Periodontal disease was seven times more likely to be associated with a preterm delivery of a low birth weight infant than mother's age, race, number of live births, and use of tobacco or alcohol. This review examines the role of asymptomatic bacteremia as possibly explaining these associations, focusing on the bacterial load on the teeth as mediated via oral hygiene.
最近，有病例对照研究和流行病学调查强烈表明，口腔健康状况不佳与心血管疾病、早产低体重儿以及任何原因导致的过早死亡之间存在关联。在一项为期7年的前瞻性研究中，在控制了已知的冠心病危险因素后，牙齿疾病是导致死亡的冠状动脉事件的重要预测指标。在另一项研究中，缺牙取代吸烟成为缺血性心脏病的一个危险因素。与母亲的年龄、种族、活产次数以及吸烟或饮酒情况相比，牙周病与早产低体重儿出生的关联可能性要高出7倍。这篇综述探讨了无症状菌血症可能作为解释这些关联的作用，重点关注通过口腔卫生介导的牙齿上的细菌载量。
