Pakmanee N, Khow O, Kumsap W, Omori-Satoh T, Chanhome L, Sriprapat S, Sitprija V
Queen Saovabha Memorial Institute, Thai Red Cross Society, Bangkok.
Toxicon. 1998 May;36(5):809-12. doi: 10.1016/s0041-0101(97)00164-5.
Naja kaouthia venom appeared in circulation rapidly after intramuscular injection into mice. The venom concentration attained a maximum level with all doses examined after 20 min. The half value of the maximum level was obtained 1 min after injection when a dose of 4LD50 was used. A critical venom concentration endangering mice was assessed from venom concentration in the sera of mice envenomed with sublethal dose (LD50). A fatal condition was produced within 30 min at a venom concentration of 200-300 ng/ml or within 50 min at a venom concentration of 100-150 ng/ml.
眼镜王蛇毒液经肌肉注射到小鼠体内后迅速进入循环系统。在所检测的所有剂量下，毒液浓度在20分钟后达到最高水平。当使用4LD50剂量时，注射后1分钟达到最高水平的一半值。根据用亚致死剂量（LD50）致毒的小鼠血清中的毒液浓度评估危及小鼠的临界毒液浓度。毒液浓度为200 - 300纳克/毫升时，30分钟内会导致致命情况；毒液浓度为100 - 150纳克/毫升时，50分钟内会导致致命情况。
