Khow O, Pakmanee N, Chanhome L, Sriprapat S, Omori-Satoh T, Sitprija V
Queen Saovabha Memorial Institute, Thai Red Cross Society, Bangkok, Thailand.
Toxicon. 1997 Nov;35(11):1649-51. doi: 10.1016/s0041-0101(97)00035-4.
The neutralizing capacity of antivenom prepared against Thai cobra (Naja kaouthia) venom was compared in mice using the homologous venom and that of spitting cobra (Naja siamensis). The amounts of antivenoms neutralizing a dose of 4 LD50 of the test venom were determined. Four antivenom preparations were used: three purified antivenoms and a crude antivenom, which were made using N. kaouthia venom only. Almost the same neutralizing capacity was obtained with the purified antivenoms, whereas a slightly lower capacity was seen with the crude antivenom. However, ratios of the amounts of four antivenoms neutralizing the homologous and heterologous test venoms were almost constant. These results indicated that Thai cobra antivenom possesses neutralizing capacity against spitting cobra venom.
使用泰国眼镜蛇（眼镜王蛇）毒液及其同源毒液和喷毒眼镜蛇（暹罗眼镜蛇）毒液，在小鼠中比较了针对泰国眼镜蛇毒液制备的抗蛇毒血清的中和能力。测定了中和一剂4倍半数致死量（LD50）测试毒液所需的抗蛇毒血清量。使用了四种抗蛇毒血清制剂：三种纯化抗蛇毒血清和一种粗制抗蛇毒血清，它们均仅使用眼镜王蛇毒液制成。纯化抗蛇毒血清的中和能力几乎相同，而粗制抗蛇毒血清的中和能力略低。然而，四种抗蛇毒血清中和同源和异源测试毒液的量的比例几乎恒定。这些结果表明，泰国眼镜蛇抗蛇毒血清对喷毒眼镜蛇毒液具有中和能力。
