Yamaya M, Sekizawa K, Ishizuka S, Monma M, Mizuta K, Sasaki H
Department of Geriatric Medicine, Tohoku University School of Medicine, and Virus Center, Clinical Research Division, Sendai National Hospital, Sendai, Japan.
Am J Respir Crit Care Med. 1998 Jul;158(1):311-4. doi: 10.1164/ajrccm.158.1.9711066.
Viral infection may induce the expression of heme oxygenase, resulting in increased carbon monoxide (CO) formation. CO may be produced by various cells of the upper and lower respiratory tract and may be detected in the exhaled air. Therefore, exhaled CO concentrations were measured on a CO monitor by vital capacity maneuver in subjects with upper respiratory tract infections (URTIs) and in nonsmoking and smoking healthy control subjects. At the time of symptoms of URTI, exhaled CO concentrations were 5.6 +/- 0.4 ppm and decreased to 1.0 +/- 0.1 ppm during recovery. Recovery values of exhaled CO were similar to those in age-matched nonsmoking healthy control subjects (1.2 +/- 0.3 ppm). Smoking healthy control subjects had the highest levels of exhaled CO concentration among the groups (18.5 +/- 2.5 ppm). These findings suggest that symptomatic URTIs increase the concentration of CO in exhaled air. This may reflect the induction of heme oxygenase that has an antiviral effect in the airways.
病毒感染可能诱导血红素加氧酶的表达，导致一氧化碳（CO）生成增加。CO可能由上、下呼吸道的各种细胞产生，并可在呼出的空气中检测到。因此，通过肺活量动作，在患有上呼吸道感染（URTI）的受试者以及非吸烟和吸烟的健康对照受试者中，使用CO监测仪测量呼出的CO浓度。在URTI症状出现时，呼出的CO浓度为5.6±0.4 ppm，恢复期间降至1.0±0.1 ppm。呼出CO的恢复值与年龄匹配的非吸烟健康对照受试者相似（1.2±0.3 ppm）。吸烟的健康对照受试者组中呼出的CO浓度最高（18.5±2.5 ppm）。这些发现表明，有症状的URTI会增加呼出空气中CO的浓度。这可能反映了气道中具有抗病毒作用的血红素加氧酶的诱导。
