即时检测的呼气末一氧化碳反映镰状细胞贫血中溶血的严重程度。
Point-of-care end-tidal carbon monoxide reflects severity of hemolysis in sickle cell anemia.
作者信息
Lal Ashutosh, Patterson Lasandra, Goldrich Alisa, Marsh Anne
机构信息
Hematology/Oncology, University of California San Francisco Benioff Children's Hospital, Oakland, California.
出版信息
Pediatr Blood Cancer. 2015 May;62(5):912-4. doi: 10.1002/pbc.25447. Epub 2015 Feb 14.
Abstract
Carbon monoxide (CO) production from heme catabolism is increased with hemolysis. A portable end-tidal CO (ETCO) monitor was used to analyze breath samples in 16 children with sickle cell anemia (SCA, 5-14 years). Median (range) ETCO for SCA was 4.35 ppm (1.8-9.7) versus 0.80 ppm (0.2-2.3) for controls (P < 0.001). ETCOc >2.1 ppm provided sensitivity and specificity of 93.8% (69.8-99.8%) for detecting SCA. ETCO correlated with reticulocytosis (P = 0.015) and bilirubin (P = 0.009), and was 32% lower in children receiving hydroxyurea (P = 0.09). Point-of-care ETCO analysis may prove useful for non-invasive monitoring of hemolysis and as a screening test for SCA.
摘要
溶血会使血红素分解代谢产生的一氧化碳（CO）增加。使用便携式潮气末一氧化碳（ETCO）监测仪对16名镰状细胞贫血（SCA，5 - 14岁）儿童的呼吸样本进行分析。SCA组的ETCO中位数（范围）为4.35 ppm（1.8 - 9.7），而对照组为0.80 ppm（0.2 - 2.3）（P < 0.001）。ETCOc >2.1 ppm检测SCA的敏感性和特异性为93.8%（69.8 - 99.8%）。ETCO与网织红细胞增多（P = 0.015）和胆红素（P = 0.009）相关，接受羟基脲治疗的儿童ETCO低32%（P = 0.09）。即时护理ETCO分析可能对溶血的无创监测以及作为SCA的筛查试验有用。
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