Kang B
J Allergy Clin Immunol. 1976 Sep;58(3):357-65. doi: 10.1016/0091-6749(76)90115-9.
Bronchial provocative test (BPT) with cockroach (CR) antigen was performed in 22 asthmatic subjects. Sixteen had positive reaction (CR-positive) and 6 had negative reaction (CR-negative) to CR antigen by skin test. Immediate bronchoconstrictive response was noted following the antigen inhalation in 14 of 16 CR-positive asthmatics, while none of 6 CR-negative asthmatics showed bronchospasm. Late asthmatic responses also were noted in 13 of 16 CR-positive asthmatic individuals following BPT with CR antigen. The dual asthmatic reactions in CR-positive individuals were mostly inhibited by the prior administration of cromolyn sodium. Three-fold increases in peripheral eosinophil counts were noted 24 hr following BPT with CR antigen. Results indicate that CR-induced asthmatic responses are allergen-specific and CR plays a causative role in allergic asthma in the population studied.
对22名哮喘患者进行了蟑螂（CR）抗原支气管激发试验（BPT）。通过皮肤试验，16名患者对CR抗原呈阳性反应（CR阳性），6名患者呈阴性反应（CR阴性）。16名CR阳性哮喘患者中有14名在吸入抗原后出现即刻支气管收缩反应，而6名CR阴性哮喘患者均未出现支气管痉挛。16名CR阳性哮喘患者中有13名在CR抗原BPT后出现迟发性哮喘反应。CR阳性个体的双重哮喘反应大多被预先给予色甘酸钠所抑制。CR抗原BPT后24小时外周嗜酸性粒细胞计数增加了三倍。结果表明，CR诱导的哮喘反应具有过敏原特异性，在研究人群中CR在过敏性哮喘中起致病作用。
