食欲素：新发现的下丘脑摄食调节因子家族。

Orexins: a newly discovered family of hypothalamic regulators of food intake.

作者信息

Wolf G

机构信息

Department of Nutritional Sciences, University of California, Berkeley, USA.

出版信息

Nutr Rev. 1998 Jun;56(6):172-3. doi: 10.1111/j.1753-4887.1998.tb06131.x.

DOI:10.1111/j.1753-4887.1998.tb06131.x

PMID:9656726

Abstract

A family of neuropeptides from the hypothalamus, named orexins, was recently discovered and characterized. Orexins stimulate appetite and food consumption. Their genes are expressed bilaterally and symmetrically in the lateral hypothalamus, which was earlier determined to be the "feeding center" of the hypothalamus. In contrast, the so-called satiety center is expressed in the ventromedial hypothalamus and is dominated by the leptin-regulated neuropeptide network.

摘要

最近发现并鉴定了一组来自下丘脑的神经肽，称为食欲肽。食欲肽能刺激食欲和食物摄入。它们的基因在下丘脑外侧双侧对称表达，而外侧下丘脑先前被确定为下丘脑的“进食中枢”。相比之下，所谓的饱足中枢在下丘脑腹内侧表达，并由瘦素调节的神经肽网络主导。