表达疟原虫或流感病毒细胞毒性T淋巴细胞表位的重组辛德毕斯病毒可使小鼠对相应病原体产生保护作用。
Recombinant Sindbis viruses expressing a cytotoxic T-lymphocyte epitope of a malaria parasite or of influenza virus elicit protection against the corresponding pathogen in mice.
作者信息
Tsuji M, Bergmann C C, Takita-Sonoda Y, Murata K, Rodrigues E G, Nussenzweig R S, Zavala F
机构信息
Department of Medical and Molecular Parasitology, New York University School of Medicine, New York, New York 10010, USA.
出版信息
J Virol. 1998 Aug;72(8):6907-10. doi: 10.1128/JVI.72.8.6907-6910.1998.
Abstract
Subcutaneous administration in mice of recombinant Sindbis viruses expressing a class I major histocompatibility complex-restricted 9-mer epitope of the Plasmodium yoelii circumsporozoite protein or the nucleoprotein of influenza virus induces a large epitope-specific CD8(+) T-cell response. This immunization also elicits a high degree of protection against infection with malaria or influenza A virus.
摘要
在小鼠中皮下注射表达约氏疟原虫环子孢子蛋白的I类主要组织相容性复合体限制的9聚体表位或流感病毒核蛋白的重组辛德毕斯病毒，可诱导产生大量的表位特异性CD8(+) T细胞应答。这种免疫接种还能引发针对疟疾或甲型流感病毒感染的高度保护作用。
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