用复制缺陷型重组痘苗病毒进行口服免疫可保护小鼠免受流感侵害。
Oral immunization with a replication-deficient recombinant vaccinia virus protects mice against influenza.
作者信息
Bender B S, Rowe C A, Taylor S F, Wyatt L S, Moss B, Small P A
机构信息
Education and Clinical Center, Veterans Affairs Medical Center, Gainesville, Florida 32608, USA.
出版信息
J Virol. 1996 Sep;70(9):6418-24. doi: 10.1128/JVI.70.9.6418-6424.1996.
Abstract
Mice immunized with two intragastrically administered doses of a replication-deficient recombinant vaccinia virus containing the hemagglutinin and nucleoprotein genes from H1N1 influenza virus developed serum anti-H1 immunoglobulin G (IgG) antibody that completely protected the lungs from challenge with H1N1. Almost all of the mice given two intragastric doses also developed mucosal anti-H1 IgA antibody, and those with high anti-H1 IgA titers had completely protected noses. Intramuscular injection of the vaccine protected the lungs but not the noses from challenge. We also found that the vaccine enhanced recovery from infection caused by a shifted (H3N2) influenza virus, probably through the induction of nucleoprotein-specific cytotoxic T-lymphocyte activity. A replication-deficient, orally administered, enteric-coated, vaccinia virus-vectored vaccine might safely protect humans against influenza.
摘要
用含有H1N1流感病毒血凝素和核蛋白基因的复制缺陷型重组痘苗病毒经两次胃内给药免疫的小鼠，产生了血清抗H1免疫球蛋白G（IgG）抗体，该抗体能完全保护肺部免受H1N1病毒攻击。几乎所有接受两次胃内给药的小鼠也产生了粘膜抗H1 IgA抗体，且抗H1 IgA滴度高的小鼠鼻子得到了完全保护。肌肉注射该疫苗可保护肺部，但不能保护鼻子免受攻击。我们还发现，该疫苗可能通过诱导核蛋白特异性细胞毒性T淋巴细胞活性，促进了由变异（H3N2）流感病毒引起的感染的恢复。一种复制缺陷型、口服、肠溶包衣的痘苗病毒载体疫苗可能会安全地保护人类免受流感侵袭。
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