猪轮状病毒致病性的病毒决定因素：猪轮状病毒第四基因致使同源宿主腹泻的证据。
Viral determinants of rotavirus pathogenicity in pigs: evidence that the fourth gene of a porcine rotavirus confers diarrhea in the homologous host.
作者信息
Bridger J C, Tauscher G I, Desselberger U
机构信息
Department of Pathology and Infectious Diseases, The Royal Veterinary College, University of London, London NW1 0TU, United Kingdom.
出版信息
J Virol. 1998 Aug;72(8):6929-31. doi: 10.1128/JVI.72.8.6929-6931.1998.
Abstract
A porcine rotavirus (prv) monoreassortant, S-F4, which carries RNA segment 4 of the pig-pathogenic variant prv 4F in the genetic background of the pig-apathogenic variant prv 4S (G. I. Tauscher and U. Desselberger, J. Virol. 71:853-857, 1997), was found to be pathogenic in gnotobiotic piglets. This indicates that RNA segment 4 of the pig-pathogenic variant prv 4F is a major determinant of pathogenicity in its homologous host.
摘要
一种猪轮状病毒（prv）单重配体S-F4，它在猪致病性较弱的prv 4S的遗传背景中携带猪致病性变体prv 4F的RNA片段4（G. I. 陶舍尔和U. 德塞尔伯格，《病毒学杂志》71:853 - 857，1997），被发现对无菌仔猪具有致病性。这表明猪致病性变体prv 4F的RNA片段4是其同源宿主中致病性的主要决定因素。
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