Onodera K, Miyazaki S, Imaizumi M
Department of Pharmacology, Tohoku University School of Dentistry, Sendai, Japan.
Methods Find Exp Clin Pharmacol. 1998 May;20(4):307-10. doi: 10.1358/mf.1998.20.4.485684.
In this study, the intracerebroventricular administration of 4-methylhistamine (3 and 10 micrograms/head), a histamine H2 receptor agonist, shortened the step-through latency in the retention trial using a step-through passive avoidance task in mice. This deteriorating effect of 4-methylhistamine (3 micrograms/head) was clearly antagonized by pretreatment with zolantidine (10 mg/kg, i.p.), a histamine H2 receptor antagonist, 20 min before an acquisition trial. Zolantidine alone at the dose tested had no effect. Thus, it is likely that activation of histamine H2 receptors has a deteriorating effect on avoidance learning in mice. The present results indicate the cognitive involvement by negative modulation of histamine H2 receptors in passive avoidance task in mice.
在本研究中，向小鼠脑室内注射组胺H2受体激动剂4-甲基组胺（3微克/只和10微克/只），在采用穿梭式被动回避任务的记忆试验中缩短了穿梭潜伏期。在获得性试验前20分钟，用组胺H2受体拮抗剂佐兰替丁（10毫克/千克，腹腔注射）预处理可明显拮抗4-甲基组胺（3微克/只）的这种恶化作用。所测试剂量的佐兰替丁单独使用没有效果。因此，组胺H2受体的激活可能对小鼠的回避学习有恶化作用。目前的结果表明，组胺H2受体的负性调节参与了小鼠被动回避任务中的认知过程。
