生长激素对普拉德-威利综合征患者身高、体重及身体成分的影响。
Effect of growth hormone on height, weight, and body composition in Prader-Willi syndrome.
作者信息
Davies P S, Evans S, Broomhead S, Clough H, Day J M, Laidlaw A, Barnes N D
机构信息
School of Human Movement Studies, Faculty of Health, Queensland University of Technology, Brisbane, Australia.
出版信息
Arch Dis Child. 1998 May;78(5):474-6. doi: 10.1136/adc.78.5.474.
AIMS
To evaluate the effect of the administration of growth hormone on stature, body weight, and body composition in children aged between 4 and 10 years with Prader-Willi syndrome.
METHODS
Height, weight, and skinfold thickness were recorded in 25 children using standard anthropometric techniques at recruitment, and six months later, shortly before the start of daily subcutaneous injections of growth hormone. Body composition was assessed via a measurement of total body water using stable isotopes. Measurements were repeated at the end of the six months of growth hormone administration. Measurements of height, weight, and skinfold thickness were expressed as standard deviation scores (SDSs).
RESULTS
There was a significant reduction in the percentage of body fat after growth hormone treatment; height velocity doubled during treatment; body weight did not change significantly when expressed as an SDS. Skinfold thickness at both the triceps and subscapular site decreased in absolute terms and when expressed as an SDS.
CONCLUSIONS
These results indicate sufficient potential benefit to justify a more prolonged trial of growth hormone treatment and an exploration of different dosage regimens in children with Prader-Willi syndrome.
目的
评估生长激素治疗对4至10岁普拉德-威利综合征患儿身高、体重和身体成分的影响。
方法
招募25名儿童，采用标准人体测量技术在入组时记录身高、体重和皮褶厚度，六个月后，即在开始每日皮下注射生长激素前不久再次记录。通过使用稳定同位素测量总体水来评估身体成分。在生长激素治疗六个月结束时重复测量。身高、体重和皮褶厚度的测量结果以标准差分数（SDS）表示。
结果
生长激素治疗后体脂百分比显著降低；治疗期间身高增长速度翻倍；以SDS表示时体重无显著变化。肱三头肌和肩胛下部位的皮褶厚度绝对值及以SDS表示时均下降。
结论
这些结果表明生长激素治疗有足够的潜在益处，足以证明对普拉德-威利综合征患儿进行更长时间的试验以及探索不同剂量方案是合理的。
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