一种利用固相萃取和气相色谱-质谱联用技术确认和鉴定尿液中滥用药物的方法。

A method for the confirmation and identification of drugs of misuse in urine using solid phase extraction and gas-liquid chromatography with mass spectrometry.

作者信息

Galloway J H, Ashford M, Marsh I D, Holden M, Forrest A R

机构信息

Department of Clinical Chemistry, Royal Hallamshire Hospital, Sheffield, UK.

出版信息

J Clin Pathol. 1998 Apr;51(4):326-9. doi: 10.1136/jcp.51.4.326.

DOI:10.1136/jcp.51.4.326

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC500681/

Abstract

A method is described for the confirmation/identification of a range of commonly misused drugs in urine samples. The method has been used for two years without problems for a range of purposes including hospital/clinic drugs of misuse screening and for toxicology in coroner's cases. Urine samples which have given a positive result on immunochemical screening for a particular drug group or groups (for example, opiates) can be processed with identification of the drugs present using a single procedure. Bond ElutCertify columns are used for the extraction of drugs from the samples followed by propionylation and gas chromatography with mass selective detection.

摘要

本文描述了一种用于确认/鉴定尿液样本中一系列常见滥用药物的方法。该方法已使用两年，用于包括医院/诊所药物滥用筛查以及验尸官案件毒理学等一系列目的，均未出现问题。对特定药物组（例如阿片类药物）免疫化学筛查呈阳性的尿液样本，可通过单一程序鉴定其中存在的药物。使用Bond ElutCertify柱从样本中提取药物，随后进行丙酰化和带质量选择性检测的气相色谱分析。

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本文引用的文献

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Simultaneous analysis of codeine, morphine, and heroin after B-glucuronidase hydrolysis.β-葡萄糖醛酸酶水解后可待因、吗啡和海洛因的同步分析。

J Forensic Sci. 1993 Nov;38(6):1275-85.

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Simultaneous determination of drugs of abuse (opiates, cocaine and amphetamine) in human hair by GC/MS and its application to a methadone treatment program.气相色谱/质谱联用同时测定人发中滥用药物（阿片类、可卡因和苯丙胺）及其在美沙酮治疗项目中的应用

Forensic Sci Int. 1993 Dec;63(1-3):185-206. doi: 10.1016/0379-0738(93)90273-d.

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Simultaneous determination of opiates, cocaine and major metabolites of cocaine in human hair by gas chromotography/mass spectrometry (GC/MS).气相色谱/质谱联用（GC/MS）法同时测定人发中阿片类物质、可卡因及其主要代谢物。

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Rapid, simultaneous quantification of morphine, codeine, and hydromorphone by GC/MS.通过气相色谱/质谱联用技术快速、同时定量测定吗啡、可待因和氢吗啡酮。

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